Current Projects from the Molecular Lab

Currently there are two projects ongoing in the laboratory:


  •  Metabolic phenotype of alveolar macrophages in COPD

Alveolar macrophages play a very important role in COPD. These cells defend the lungs from the damage caused by foreign particles and microorganisms. Defective function of alveolar macrophages in COPD is known for years but the mechanism for this defect is yet unclear. Metabolic alterations in macrophages are known to alter the immune function of these cells. A better understanding of the impact on metabolic activities of macrophages will help in developing potential novel treatments for COPD.


  • Role of protein post-translational modification in the alteration of metabolism in alveolar macrophages


Smoke generated from cigarettes, bidis and biomass is known to subject lung cells to oxidative stress. This is because of the oxidants present in the smoke. One of the defense mechanisms in the cells is to undergo a post-translational modification of important proteins which could protect their amino acids which may be susceptible to damage by the oxidants. This post-translational modification can be reversible and irreversible. We are interested in identifying proteins which undergo such a post-translational modification in order to further understand their role in the pathophysiology of COPD.

CRF at ERS 2016 London
7 of the 12 abstracts submitted were selected at t
CRF at ERS 2015 Amsterdam
9 of the 13 abstracts submitted were selected at t
Chest Research Foundation, Pun...
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