Chest Research Foundation has one of the finest "state-of-the-art" pulmonary function laboratories in the country.



The instrument that measures the flow/volume of the air that we breathe in/out is called a spirometer. It is the one of the simplest tool to diagnose an obstruction in the airways.. Most widely used and most objective device used to diagnose obstructive airway diseases. (Asthma, COPD), grade their severity and monitor response to therapy. At CRF we have various types of spirometers

      1)      Volume Displacement spirometers- eg. Bellows spirometer

2)      Flow sensing spirometers

a)      Pneumotach spirometers

b)      Turbine based spirometers

c)      Ultrasonic spirometers

d)     Anemometers


Body Plethysmography

In a body plethysmograph (body box), the volumes of the lung are calculated by pressure change using Boyle’s law. This instrument measures the total lung capacity including the residual volume which is not limited by air trapping; it is one of the most advanced tools available at this time to assess lung volumes, airway resistance and conductance.


CO Monitor

Carbon monoxide is considered to be a biomarker of oxidative stress. Oxidative stress is high in asthmatics, COPD patients and smokers. This device measures CO in exhaled air hence gives an indirect measure of oxidative stress in lungs.


Impulse Oscillometry

Impulse oscillometry is a very novel technique which can very efficiently measure the resistances of the upper and lower airway and this perhaps is the only tool in pulmonary medicine to do this. It not only measures the airway resistance but also determines the elastic reactance of the lung. In short it can effectively describe the different properties of the lungs and airway which determines airway pathologies. Impulse oscillometry is relatively simple technique which requires only tidal breathing.



It measures how well oxygen passes from the air sacs in the lungs into the blood, in order to do so carbon monoxide is used because it has 300 times more affinity for hemoglobin as compared to oxygen. There is a percent of predicted amount of carbon monoxide inhaled that should be absorbed; this amount depends upon age, height and sex of the person. Decrease in DLCO is observed particularly in interstitial lung diseases.


Bronchoprovocation Testing

Airway hyper responsiveness is a characteristic feature of atopic asthma. It may vary over time, often increasing during exacerbation and decreasing during treatment with anti-inflammatory medications. Airway hyper responsiveness can be measured by bronchoprovocation testing. In bronchoprovocation testing synthetic bronchoconstrictors like Methacholine, 5’ AMP, Histamine are nebulised through the Aerosol Provocation System which cause airway constriction. Different concentrations of bronchoconstrictors are used. Amount of constriction is measured by spirometry.



It is difficult to determine the level of nasal resistance by rhinoscopy or by subjective assessment, which can be very misleading. A more objective measurement of nasal resistance can be made by measuring nasal pressure and flow parameters and calculating the nasal resistance indirectly. This is done with the help of a Rhinomanometer.   

   1) Rhinomanometry is useful to diagnose allergic and non allergic rhinitis.

   2) To monitor patients with Rhinitis.

   3) Detect the nasal hyper responsiveness after AMP challenge.







CRF at ERS 2016 London
7 of the 12 abstracts submitted were selected at t
CRF at ERS 2015 Amsterdam
9 of the 13 abstracts submitted were selected at t
Chest Research Foundation, Pun...
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